Polymyxin B sulfate
CAS No. 1405-20-5
Polymyxin B sulfate ( Aerosporin | Mastimyxin )
产品货号. M11699 CAS No. 1405-20-5
硫酸多粘菌素 B 是从多粘芽孢杆菌菌株中获得的多粘菌素 B1 和 B2 的混合物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
1G | ¥348 | 有现货 |
|
生物学信息
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产品名称Polymyxin B sulfate
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述硫酸多粘菌素 B 是从多粘芽孢杆菌菌株中获得的多粘菌素 B1 和 B2 的混合物。
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产品描述Polymyxin B sulphate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.(In Vitro):Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080.(In Vivo):Polymyxin B Sulfate (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model.Polymyxin B Sulfate (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080.
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体外实验Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080.
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体内实验Polymyxin B Sulfate (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model.Polymyxin B Sulfate (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080. Animal Model:Eight-week-old, 24-30 g, female Swiss mice Dosage:0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection modeAdministration:S.c.Result:Showed antibacterial activities for three K. pneumoniae strains.Animal Model:7-9 weeks, female NMRI mice (E. coli IH3080) Dosage:2mg/kg Administration:S.c.Result:Decreased the bacterial count in a dose dependent manner.
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同义词Aerosporin | Mastimyxin
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通路Others
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靶点Other Targets
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受体Others
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研究领域Infection
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适应症——
化学信息
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CAS Number1405-20-5
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分子量1301.56
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分子式C56H100N16O17S
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纯度>98% (HPLC)
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溶解度Water: 25 mg/mL
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SMILESCCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
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化学全称N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Severino P, et al. Colloids Surf B Biointerfaces. 2015 May 1;129:191-7.
产品手册
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