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Polymyxin B sulfate

CAS No. 1405-20-5

Polymyxin B sulfate ( Aerosporin | Mastimyxin )

产品货号. M11699 CAS No. 1405-20-5

硫酸多粘菌素 B 是从多粘芽孢杆菌菌株中获得的多粘菌素 B1 和 B2 的混合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
1G ¥348 有现货

生物学信息

  • 产品名称
    Polymyxin B sulfate
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    硫酸多粘菌素 B 是从多粘芽孢杆菌菌株中获得的多粘菌素 B1 和 B2 的混合物。
  • 产品描述
    Polymyxin B sulphate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.(In Vitro):Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080.(In Vivo):Polymyxin B Sulfate (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model.Polymyxin B Sulfate (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080.
  • 体外实验
    Polymyxin B Sulfate shows antibacterial activities with MICs of 0.5 mg/l for E. coli strain IH3080.
  • 体内实验
    Polymyxin B Sulfate (0.5-120 mg/kg; s.c.) shows antibacterial activities in thigh or lung infection mouse model.Polymyxin B Sulfate (2 mg/kg, s.c.) shows potent in mouse bactericidal effect against E. coli strain IH3080. Animal Model:Eight-week-old, 24-30 g, female Swiss mice Dosage:0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection modeAdministration:S.c.Result:Showed antibacterial activities for three K. pneumoniae strains.Animal Model:7-9 weeks, female NMRI mice (E. coli IH3080) Dosage:2mg/kg Administration:S.c.Result:Decreased the bacterial count in a dose dependent manner.
  • 同义词
    Aerosporin | Mastimyxin
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    Infection
  • 适应症
    ——

化学信息

  • CAS Number
    1405-20-5
  • 分子量
    1301.56
  • 分子式
    C56H100N16O17S
  • 纯度
    >98% (HPLC)
  • 溶解度
    Water: 25 mg/mL
  • SMILES
    CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC2=CC=CC=C2)CC(C)C)CCN)CCN)C(C)O.OS(=O)(=O)O
  • 化学全称
    N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Severino P, et al. Colloids Surf B Biointerfaces. 2015 May 1;129:191-7.
产品手册
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